NP_066018.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
nuclear receptor coactivator 5
NCBI Official Synonym Full Names
nuclear receptor coactivator 5
NCBI Protein Information
nuclear receptor coactivator 5; NCoA-5; coactivator independent of AF-2
UniProt Protein Name
Nuclear receptor coactivator 5
UniProt Synonym Protein Names
Coactivator independent of AF-2; CIA
UniProt Synonym Gene Names
UniProt Entry Name
NCOA5_HUMAN
NCBI Summary for NCOA5
This gene encodes a coregulator for the alpha and beta estrogen receptors and the orphan nuclear receptor NR1D2. The protein localizes to the nucleus, and is thought to have both coactivator and corepressor functions. Its interaction with nuclear receptors is independent of the AF2 domain on the receptors, which is known to regulate interaction with other coreceptors. Two alternatively spliced transcript variants for this gene have been described. However, the full length nature of one of the variants has not been determined. [provided by RefSeq, Jul 2008]
UniProt Comments for NCOA5
NCOA5: Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2).
Protein type: Transcription, coactivator/corepressor; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 20q13.12
Cellular Component: nucleoplasm; extracellular space; nucleus; actin cytoskeleton
Molecular Function: protein binding; chromatin binding
Biological Process: transcription, DNA-dependent; regulation of transcription, DNA-dependent; negative regulation of insulin receptor signaling pathway; glucose homeostasis
Research Articles on NCOA5
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Products associated with anti-NCOA5 antibody
Diseases associated with anti-NCOA5 antibody
Organs/Tissues associated with anti-NCOA5 antibody
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