NP_477352.3
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
phosphatidylinositol 4-kinase alpha
NCBI Official Synonym Full Names
phosphatidylinositol 4-kinase, catalytic, alpha
NCBI Protein Information
phosphatidylinositol 4-kinase alpha; PI4-kinase alpha; ptdIns-4-kinase alpha; phosphatidylinositol 4-kinase 230; phosphatidylinositol 4-kinase, type III, alpha
UniProt Protein Name
Phosphatidylinositol 4-kinase alpha
UniProt Synonym Gene Names
PIK4; PIK4CA; PI4-kinase alpha; PI4K-alpha; PtdIns-4-kinase alpha [Similar Products]
UniProt Entry Name
PI4KA_HUMAN
NCBI Summary for PI4KA
This gene encodes a phosphatidylinositol (PI) 4-kinase which catalyzes the first committed step in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. The mammalian PI 4-kinases have been classified into two types, II and III, based on their molecular mass, and modulation by detergent and adenosine. The protein encoded by this gene is a type III enzyme that is not inhibited by adenosine. [provided by RefSeq, Sep 2014]
UniProt Comments for PI4KA
PIK4CA: Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate. Expressed ubiquitously. Highest levels in placenta and brain. Little or no expression in lung, liver, pancreas, testis or leukocytes. This is a type II PtdIns-4-kinase activated by detergents such as triton and inhibited by adenosine. Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Carbohydrate Metabolism - inositol phosphate; Motility/polarity/chemotaxis; Kinase, lipid; EC 2.7.1.67
Chromosomal Location of Human Ortholog: 22q11.21
Cellular Component: focal adhesion; membrane; plasma membrane; cytosol
Molecular Function: 1-phosphatidylinositol 4-kinase activity; protein binding; ATP binding
Biological Process: phosphoinositide-mediated signaling; phosphoinositide phosphorylation; phospholipid metabolic process; phosphatidylinositol biosynthetic process; signal transduction
Disease: Polymicrogyria, Perisylvian, With Cerebellar Hypoplasia And Arthrogryposis
Research Articles on PI4KA
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Pathways associated with anti-PI4KA antibody
Products by Pathway |
Pathway Diagram |
3-phosphoinositide Biosynthesis Pathway antibodies |
3-phosphoinositide Biosynthesis Pathway Diagram |
3-phosphoinositide Biosynthesis Pathway antibodies |
3-phosphoinositide Biosynthesis Pathway Diagram |
D-myo-inositol (1,4,5)-trisphosphate Biosynthesis Pathway antibodies |
D-myo-inositol (1,4,5)-trisphosphate Biosynthesis Pathway Diagram |
D-myo-inositol (1,4,5)-trisphosphate Biosynthesis Pathway antibodies |
D-myo-inositol (1,4,5)-trisphosphate Biosynthesis Pathway Diagram |
Inositol Phosphate Metabolism Pathway antibodies |
Inositol Phosphate Metabolism Pathway Diagram |
Inositol Phosphate Metabolism Pathway antibodies |
Inositol Phosphate Metabolism Pathway Diagram |
Inositol Phosphate Metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 Pathway antibodies |
Inositol Phosphate Metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 Pathway Diagram |
Inositol Phosphate Metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 Pathway antibodies |
Inositol Phosphate Metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 Pathway Diagram |
Integrins In Angiogenesis Pathway antibodies |
Integrins In Angiogenesis Pathway Diagram |
Metabolic Pathways antibodies |
Metabolic Pathways Diagram |
Diseases associated with anti-PI4KA antibody
Organs/Tissues associated with anti-PI4KA antibody
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