AAH36000.4
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Protein disulfide isomerase family A, member 3
NCBI Official Synonym Full Names
protein disulfide isomerase family A, member 3
NCBI Official Synonym Symbols
P58; ER60; ERp57; ERp60; ERp61; GRP57; GRP58; PI-PLC; HsT17083; HEL-S-269; HEL-S-93n [Similar Products]
NCBI Protein Information
protein disulfide-isomerase A3; ER protein 57; ER protein 60; phospholipase C-alpha; 58 kDa microsomal protein; disulfide isomerase ER-60; endoplasmic reticulum P58; 58 kDa glucose-regulated protein; glucose regulated protein, 58kDa; epididymis secretory protein Li 269; protein disulfide isomerase-associated 3; endoplasmic reticulum resident protein 57; endoplasmic reticulum resident protein 60; epididymis secretory sperm binding protein Li 93n
UniProt Protein Name
Protein disulfide-isomerase A3
UniProt Synonym Protein Names
58 kDa glucose-regulated protein; 58 kDa microsomal protein; p58; Disulfide isomerase ER-60; Endoplasmic reticulum resident protein 57; ER protein 57; ERp57; Endoplasmic reticulum resident protein 60; ER protein 60; ERp60
UniProt Synonym Gene Names
ERP57; ERP60; GRP58; p58; ER protein 57; ERp57; ER protein 60; ERp60 [Similar Products]
UniProt Entry Name
PDIA3_HUMAN
NCBI Summary for PDIA3
This gene encodes a protein of the endoplasmic reticulum that interacts with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins. The protein was once thought to be a phospholipase; however, it has been demonstrated that the protein actually has protein disulfide isomerase activity. It is thought that complexes of lectins and this protein mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrates. [provided by RefSeq, Jul 2008]
UniProt Comments for PDIA3
GRP58: a protein disulfide isomerase found in the endoplasmic reticulum lumen. Catalyzes the rearrangement of both intrachain and interchain disulfide bonds in proteins to form the native structures. An essential component of the peptide-loading complex of the major histocompatibility complex class I pathway.
Protein type: Chaperone; Apoptosis; Isomerase; Protease; EC 5.3.4.1; Phospholipase; Endoplasmic reticulum
Chromosomal Location of Human Ortholog: 15q15
Cellular Component: focal adhesion; smooth endoplasmic reticulum; cell surface; endoplasmic reticulum; endoplasmic reticulum lumen; melanosome; nucleus
Molecular Function: disulfide oxidoreductase activity; protein binding; cysteine-type endopeptidase activity; protein disulfide isomerase activity; phospholipase C activity
Biological Process: antigen processing and presentation of peptide antigen via MHC class I; cellular protein metabolic process; protein folding; protein import into nucleus; cell redox homeostasis; antigen processing and presentation of exogenous peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; protein amino acid N-linked glycosylation via asparagine; proteolysis; signal transduction; post-translational protein modification; protein retention in ER
Research Articles on PDIA3
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Products associated with anti-PDIA3 antibody
Pathways associated with anti-PDIA3 antibody
Diseases associated with anti-PDIA3 antibody
Organs/Tissues associated with anti-PDIA3 antibody
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