NP_055145.3
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
protein phosphatase 1 regulatory subunit 15A
NCBI Official Synonym Full Names
protein phosphatase 1, regulatory subunit 15A
NCBI Official Synonym Symbols
NCBI Protein Information
protein phosphatase 1 regulatory subunit 15A; growth arrest and DNA-damage-inducible 34; growth arrest and DNA damage-inducible protein GADD34; protein phosphatase 1, regulatory (inhibitor) subunit 15A; myeloid differentiation primary response protein MyD116 homolog
UniProt Protein Name
Protein phosphatase 1 regulatory subunit 15A
UniProt Synonym Protein Names
Growth arrest and DNA damage-inducible protein GADD34; Myeloid differentiation primary response protein MyD116 homolog
UniProt Synonym Gene Names
UniProt Entry Name
PR15A_HUMAN
NCBI Summary for PPP1R15A
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The induction of this gene by ionizing radiation occurs in certain cell lines regardless of p53 status, and its protein response is correlated with apoptosis following ionizing radiation. [provided by RefSeq, Jul 2008]
UniProt Comments for PPP1R15A
GADD34: Recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing TP53 phosphorylation on 'Ser-15'. Belongs to the PPP1R15 family.
Protein type: Translation initiation; Apoptosis; DNA repair, damage; Cell cycle regulation
Chromosomal Location of Human Ortholog: 19q13.2
Cellular Component: Golgi apparatus; endoplasmic reticulum membrane; mitochondrial outer membrane; mitochondrion; membrane; endoplasmic reticulum; cytoplasm; protein phosphatase type 1 complex; cytosol
Molecular Function: protein binding; protein phosphatase type 1 regulator activity; protein kinase binding; protein phosphatase 1 binding
Biological Process: negative regulation of protein amino acid dephosphorylation; positive regulation of phosphoprotein phosphatase activity; apoptosis; unfolded protein response; transforming growth factor beta receptor signaling pathway; positive regulation of translation initiation in response to stress; negative regulation of phosphoprotein phosphatase activity; cell cycle arrest; negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of peptidyl-serine phosphorylation; response to DNA damage stimulus; positive regulation of transcription from RNA polymerase I promoter
Research Articles on PPP1R15A
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Products associated with anti-PPP1R15A antibody
Pathways associated with anti-PPP1R15A antibody
Diseases associated with anti-PPP1R15A antibody
Organs/Tissues associated with anti-PPP1R15A antibody
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