NP_714923.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
tubulin--tyrosine ligase
NCBI Official Synonym Full Names
tubulin tyrosine ligase
NCBI Protein Information
tubulin--tyrosine ligase; 2410003M22Rik; tubulin-tyrosine ligase
UniProt Protein Name
Tubulin--tyrosine ligase
UniProt Synonym Gene Names
UniProt Entry Name
TTL_HUMAN
NCBI Summary for TTL
TTL is a cytosolic enzyme involved in the posttranslational modification of alpha-tubulin (see MIM 602529). Alpha-tubulin within assembled microtubules is detyrosinated over time at the C terminus. After microtubule disassembly, TTL restores the tyrosine residues and consequently participates in a cycle of tubulin detyrosination and tyrosination (Erck et al., 2003 [PubMed 14571137]).[supplied by OMIM, Mar 2008]
UniProt Comments for TTL
TTL: Catalyzes the post-translational addition of a tyrosine to the C-terminal end of detyrosinated alpha-tubulin. Belongs to the tubulin--tyrosine ligase family.
Protein type: EC 6.3.2.25; Ligase; Cell development/differentiation
Chromosomal Location of Human Ortholog: 2q13
Molecular Function: tubulin-tyrosine ligase activity; ATP binding
Biological Process: protein modification process; regulation of axon extension; microtubule cytoskeleton organization and biogenesis
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Diseases associated with anti-TTL antibody
Organs/Tissues associated with anti-TTL antibody
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