AAH10175.1
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Ubiquitin-conjugating enzyme E2A (RAD6 homolog)
NCBI Official Synonym Full Names
ubiquitin-conjugating enzyme E2A
NCBI Official Synonym Symbols
UBC2; HHR6A; MRXSN; RAD6A; MRXS30 [Similar Products]
NCBI Protein Information
ubiquitin-conjugating enzyme E2 A; RAD6 homolog A; ubiquitin-protein ligase A; ubiquitin carrier protein A
UniProt Protein Name
Ubiquitin-conjugating enzyme E2 A
UniProt Synonym Protein Names
RAD6 homolog A; HR6A; hHR6A; Ubiquitin carrier protein A; Ubiquitin-protein ligase A
UniProt Synonym Gene Names
UniProt Entry Name
UBE2A_HUMAN
NCBI Summary for UBE2A
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin-protein ligases. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair, and may play a role in transcriptional regulation. Mutations in this gene are associated with mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
UniProt Comments for UBE2A
UBE2A: a ubiquitin-protein ligase, a member of the ubiquitin-conjugating enzyme family. Homologous to the yeast DNA repair gene RAD6. Interacts with RAD18. Required for postreplication repair of UV-damaged DNA.
Protein type: Ligase; Ubiquitin ligase; EC 6.3.2.19; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: Xq24
Cellular Component: XY body; cytoplasm; nuclear chromatin; chromatin; cytosol
Molecular Function: protein binding; small conjugating protein ligase activity; ubiquitin protein ligase binding; ubiquitin-protein ligase activity; ATP binding; ligase activity
Biological Process: ubiquitin-dependent protein catabolic process; proteasomal ubiquitin-dependent protein catabolic process; protein autoubiquitination; antigen processing and presentation of peptide antigen via MHC class I; protein polyubiquitination; maternal process involved in pregnancy; in utero embryonic development; postreplication repair; positive regulation of cell proliferation; DNA repair; histone H2A ubiquitination; response to UV
Disease: Mental Retardation, X-linked, Syndromic, Nascimento Type
Research Articles on UBE2A
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Products associated with anti-UBE2A antibody
Pathways associated with anti-UBE2A antibody
Diseases associated with anti-UBE2A antibody
Organs/Tissues associated with anti-UBE2A antibody
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