NP_001002932.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
von Willebrand factor
NCBI Official Synonym Symbols
NCBI Protein Information
von Willebrand factor
UniProt Protein Name
von Willebrand factor
UniProt Synonym Gene Names
UniProt Entry Name
VWF_CANFA
UniProt Comments for VWF
Function: Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex, glycoprotein Ibalpha/IX/V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma
Subunit structure: Multimeric. Interacts with F8. Ref.2
Subcellular location: Secreted. Secreted › extracellular space › extracellular matrix. Note: Localized to storage granules. Ref.2
Tissue specificity: Plasma.
Domain: The propeptide is required for multimerization of vWF and for its targeting to storage granules.
Post-translational modification: All cysteine residues are involved in intrachain or interchain disulfide bonds
By similarity.N- and O-glycosylated
Involvement in disease: Note=Defects in VWF are the cause of von Willebrand disease (VWD) in the Scottish Terrier. VWD is characterized by frequent bleeding. Type I VWD is associated with a deficiency of VWF; type II by normal to decreased plasma level of VWF; type III by a virtual absence of VWF. Ref.4
Sequence similarities: Contains 1 CTCK (C-terminal cystine knot-like) domain.Contains 4 TIL (trypsin inhibitory-like) domains.Contains 3 VWFA domains.Contains 3 VWFC domains.Contains 4 VWFD domains.
Product References and Citations for anti-VWF antibody
1. Montgomery RR, Coller BS, in Hemostasis and Thrombosis, 3rd Edition, eds. RW Colman, J Hirsh, VJ Marder and EW Salzman, pp. 134-168, J.B. Lippincott Co., Philadelphia PA, USA, 1994. 2. Sadler JE; von Willebrand Factor (Minireview); JBC 266:34, pp 22777- 22780, 1991.
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Pathways associated with anti-VWF antibody
Diseases associated with anti-VWF antibody
Organs/Tissues associated with anti-VWF antibody
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