Q14683.2
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Structural maintenance of chromosomes protein 1A
NCBI Official Synonym Full Names
structural maintenance of chromosomes 1A
NCBI Official Synonym Symbols
SMC1; SMCB; CDLS2; SB1.8; SMC1L1; DXS423E; SMC1alpha [Similar Products]
NCBI Protein Information
structural maintenance of chromosomes protein 1A; SMC-1-alpha; SMC protein 1A; segregation of mitotic chromosomes 1; SMC1 (structural maintenance of chromosomes 1, yeast)-like 1
UniProt Protein Name
Structural maintenance of chromosomes protein 1A
UniProt Synonym Protein Names
Sb1.8
UniProt Synonym Gene Names
DXS423E; KIAA0178; SB1.8; SMC1; SMC1L1; SMC protein 1A; SMC-1-alpha; SMC-1A [Similar Products]
UniProt Entry Name
SMC1A_HUMAN
NCBI Summary for SMC1A
Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1B or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. Mutations in this gene result in Cornelia de Lange syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
UniProt Comments for SMC1A
Smc1: a component of the cohesin multiprotein complex that is required for sister chromatid cohesion. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Thought to be an important part of functional kinetochores. Interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair.
Protein type: DNA replication; RNA splicing
Chromosomal Location of Human Ortholog: Xp11.22-p11.21
Cellular Component: kinetochore; nucleoplasm; condensed nuclear chromosome; cohesin core heterodimer; cytoplasm; nucleolus; chromosome; cytosol; nucleus; chromosome, pericentric region
Molecular Function: protein binding; protein heterodimerization activity; microtubule motor activity; chromatin binding; ATP binding
Biological Process: meiosis; mitotic sister chromatid segregation; mitotic cell cycle checkpoint; RNA splicing; mitotic sister chromatid cohesion; stem cell maintenance; sister chromatid cohesion; DNA damage response, signal transduction; negative regulation of DNA endoreduplication; DNA repair; nuclear mRNA splicing, via spliceosome; response to radiation; mitotic spindle organization and biogenesis; cell division; gene expression; mitotic cell cycle
Disease: Cornelia De Lange Syndrome 2
Research Articles on SMC1A
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Products associated with anti-SMC1A antibody
Pathways associated with anti-SMC1A antibody
Diseases associated with anti-SMC1A antibody
Organs/Tissues associated with anti-SMC1A antibody
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