NP_001077431.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
48,098 Da
NCBI Official Full Name
transcription factor 4 isoform a
NCBI Official Synonym Full Names
transcription factor 4
NCBI Official Synonym Symbols
E2-2; ITF2; PTHS; SEF2; FECD3; ITF-2; SEF-2; TCF-4; SEF2-1; SEF2-1A; SEF2-1B; SEF2-1D; bHLHb19 [Similar Products]
NCBI Protein Information
transcription factor 4
UniProt Protein Name
Transcription factor 4
UniProt Synonym Protein Names
Class B basic helix-loop-helix protein 19; bHLHb19; Immunoglobulin transcription factor 2; ITF-2; SL3-3 enhancer factor 2; SEF-2
UniProt Synonym Gene Names
NCBI Summary for TCF4/12
This gene encodes transcription factor 4, a basic helix-loop-helix transcription factor. The encoded protein recognizes an Ephrussi-box ('E-box') binding site ('CANNTG') - a motif first identified in immunoglobulin enhancers. This gene is broadly expressed, and may play an important role in nervous system development. Defects in this gene are a cause of Pitt-Hopkins syndrome. In addition, an intronic CTG repeat normally numbering 10-37 repeat units can expand to >50 repeat units and cause Fuchs endothelial corneal dystrophy. Multiple alternatively spliced transcript variants that encode different proteins have been described. [provided by RefSeq, Jul 2016]
UniProt Comments for TCF4/12
Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription (). Preferentially binds to either 5'-ACANNTGT-3' or 5'-CCANNTGG-3'.
Product References and Citations for anti-TCF4/12 antibody
Corneliussen B., J. Virol. 65:6084-6093(1991). Breschel T.S., Hum. Mol. Genet. 6:1855-1863(1997). Amiel J., Am. J. Hum. Genet. 80:988-993(2007).
Research Articles on TCF4/12
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Products associated with anti-TCF4/12 antibody
Pathways associated with anti-TCF4/12 antibody
Diseases associated with anti-TCF4/12 antibody
Organs/Tissues associated with anti-TCF4/12 antibody
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