NP_000353.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
24,145 Da
NCBI Official Full Name
metalloproteinase inhibitor 3
NCBI Official Synonym Full Names
TIMP metallopeptidase inhibitor 3
NCBI Protein Information
metalloproteinase inhibitor 3
UniProt Protein Name
Metalloproteinase inhibitor 3
UniProt Synonym Protein Names
Protein MIG-5; Tissue inhibitor of metalloproteinases 3; TIMP-3
UniProt Synonym Gene Names
NCBI Summary for TIMP3
This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy. [provided by RefSeq, Jul 2008]
UniProt Comments for TIMP3
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15.
Product References and Citations for anti-TIMP3 antibody
Uria J.A., Cancer Res. 54:2091-2094(1994). Wilde C.G., DNA Cell Biol. 13:711-718(1994). Silbiger S.M., Gene 141:293-297(1994).
Research Articles on TIMP3
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Products associated with anti-TIMP3 antibody
Pathways associated with anti-TIMP3 antibody
Diseases associated with anti-TIMP3 antibody
Organs/Tissues associated with anti-TIMP3 antibody
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