NP_005419.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
98,314 Da
NCBI Official Full Name
proto-oncogene vav isoform 1
NCBI Official Synonym Full Names
vav 1 guanine nucleotide exchange factor
NCBI Official Synonym Symbols
NCBI Protein Information
proto-oncogene vav; vav 1 oncogene
UniProt Protein Name
Proto-oncogene vav
UniProt Synonym Gene Names
UniProt Entry Name
VAV_HUMAN
NCBI Summary for VAV1
This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012]
UniProt Comments for VAV1
VAV1: a proto-oncogenic guanine nucleotide exchange factors (GEF) of the Dbl family. A GEF for the Rho family of GTP binding proteins. Expressed exclusively in hematopoietic cells. Important in hematopoiesis, playing a role in T-cell and B-cell development and activation.
Protein type: GEFs, Rac/Rho; Oncoprotein; Motility/polarity/chemotaxis; GEFs
Chromosomal Location of Human Ortholog: 19p13.2
Cellular Component: plasma membrane; intercellular junction; cytosol
Molecular Function: protein binding; metal ion binding; Rac guanyl-nucleotide exchange factor activity; guanyl-nucleotide exchange factor activity; transcription factor activity
Biological Process: integrin-mediated signaling pathway; epidermal growth factor receptor signaling pathway; platelet activation; neutrophil chemotaxis; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; T cell activation; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; G-protein coupled receptor protein signaling pathway; regulation of small GTPase mediated signal transduction; regulation of transcription, DNA-dependent; small GTPase mediated signal transduction; T cell costimulation; innate immune response; blood coagulation; vascular endothelial growth factor receptor signaling pathway
Research Articles on VAV1
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Products associated with anti-VAV1 antibody
Pathways associated with anti-VAV1 antibody
Diseases associated with anti-VAV1 antibody
Organs/Tissues associated with anti-VAV1 antibody
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