NP_005331
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
13,802 Da
NCBI Official Full Name
histidine triad nucleotide-binding protein 1
NCBI Official Synonym Full Names
histidine triad nucleotide binding protein 1
NCBI Protein Information
histidine triad nucleotide-binding protein 1; protein kinase C inhibitor 1; adenosine 5'-monophosphoramidase; protein kinase C-interacting protein 1
UniProt Protein Name
Histidine triad nucleotide-binding protein 1
UniProt Synonym Protein Names
Adenosine 5'-monophosphoramidase; Protein kinase C inhibitor 1; Protein kinase C-interacting protein 1; PKCI-1
UniProt Synonym Gene Names
UniProt Entry Name
HINT1_HUMAN
NCBI Summary for HINT1
The protein encoded by this gene can hydrolyze substrates such as AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha-acetyl lysine methyl ester, and AMP-NH2. The encoded protein interacts with these substrates via a histidine triad motif, which is part of the loop that binds to the substrate. This gene has been found to be a tumor suppressing gene. Several transcript variants, but only one of them protein-coding, have been found for this gene. [provided by RefSeq, Dec 2012]
UniProt Comments for HINT1
HINT1: Hydrolyzes adenosine 5'-monophosphoramidate substrates such as AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha- acetyl lysine methyl ester and AMP-NH2. Belongs to the HINT family.
Protein type: Cytoskeletal; Hydrolase; EC 3.-.-.-
Chromosomal Location of Human Ortholog: 5q31.2
Cellular Component: cytoskeleton; cytoplasm; histone deacetylase complex; plasma membrane; nucleus
Molecular Function: protein kinase C binding; hydrolase activity; nucleotide binding
Biological Process: transcription, DNA-dependent; regulation of transcription, DNA-dependent; purine ribonucleotide catabolic process; signal transduction
Disease: Neuromyotonia And Axonal Neuropathy, Autosomal Recessive
Research Articles on HINT1
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Products associated with HINT1 blocking peptide
Diseases associated with HINT1 blocking peptide
Organs/Tissues associated with HINT1 blocking peptide
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