AAI36612
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
50,582 Da
NCBI Official Full Name
Jumonji domain containing 2B
NCBI Official Synonym Full Names
lysine (K)-specific demethylase 4B
NCBI Protein Information
lysine-specific demethylase 4B; tudor domain containing 14B; jumonji domain containing 2B; jumonji domain-containing protein 2B; jmjC domain-containing histone demethylation protein 3B
UniProt Protein Name
Lysine-specific demethylase 4B
UniProt Synonym Protein Names
JmjC domain-containing histone demethylation protein 3B; Jumonji domain-containing protein 2B
UniProt Synonym Gene Names
UniProt Entry Name
KDM4B_HUMAN
UniProt Comments for KDM4B
JMJD2B: Histone demethylase that specifically demethylates 'Lys- 9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate. Belongs to the JHDM3 histone demethylase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Oxidoreductase; Demethylase; EC 1.14.11.-
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component: nucleoplasm; focal adhesion; cell junction; nucleus
Molecular Function: dioxygenase activity; zinc ion binding
Biological Process: establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; regulation of transcription, DNA-dependent; chromatin modification
Research Articles on KDM4B
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Products associated with KDM4B blocking peptide
Pathways associated with KDM4B blocking peptide
Diseases associated with KDM4B blocking peptide
Organs/Tissues associated with KDM4B blocking peptide
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