NP_775956
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
27,932 Da
NCBI Official Full Name
E3 SUMO-protein ligase NSE2
NCBI Official Synonym Full Names
non-SMC element 2, MMS21 homolog (S. cerevisiae)
NCBI Protein Information
E3 SUMO-protein ligase NSE2; hMMS21; MMS21 homolog; non-SMC element 2 homolog; zinc finger, MIZ-type containing 7; methyl methanesulfonate sensitivity gene 21; non-structural maintenance of chromosomes element 2 homolog
UniProt Protein Name
E3 SUMO-protein ligase NSE2
UniProt Synonym Protein Names
MMS21 homolog; hMMS21; Non-structural maintenance of chromosomes element 2 homolog; Non-SMC element 2 homolog
UniProt Synonym Gene Names
UniProt Entry Name
NSE2_HUMAN
UniProt Comments for NSMCE2
NSMCE2: E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand break repair by homologous recombination. Is not be required for the stability of the complex. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Acts as a E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, the shelterin complex subunits TERF1, TERF2, TINF2 and TERF2IP, and maybe the cohesin components RAD21 and STAG2. Required for recruitment of telomeres to PML nuclear bodies. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair, and for formation of APBs in ALT cell lines. Required for sister chromatid cohesion during prometaphase and mitotic progression. Belongs to the NSE2 family.
Protein type: EC 6.3.2.-; SUMO conjugating system; Ubiquitin ligase; Ligase; EC 6.-.-.-
Chromosomal Location of Human Ortholog: 8q24.13
Cellular Component: PML body; chromosome, telomeric region; nucleus
Molecular Function: protein binding; zinc ion binding; SUMO ligase activity; ligase activity
Biological Process: mitosis; protein sumoylation; positive regulation of maintenance of mitotic sister chromatid cohesion; cell division; telomere maintenance via recombination; positive regulation of mitotic metaphase/anaphase transition; double-strand break repair via homologous recombination; double-strand break repair via nonhomologous end joining
Research Articles on NSMCE2
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Products associated with NSMCE2 blocking peptide
Diseases associated with NSMCE2 blocking peptide
Organs/Tissues associated with NSMCE2 blocking peptide
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