NP_065907
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
118,566 Da
NCBI Official Full Name
teashirt homolog 3
NCBI Official Synonym Full Names
teashirt zinc finger homeobox 3
NCBI Official Synonym Symbols
NCBI Protein Information
teashirt homolog 3; teashirt 3; zinc finger protein 537; teashirt family zinc finger 3
UniProt Protein Name
Teashirt homolog 3
UniProt Synonym Protein Names
Zinc finger protein 537
UniProt Synonym Gene Names
UniProt Entry Name
TSH3_HUMAN
UniProt Comments for TSHZ3
TSHZ3: Transcriptional regulator involved in developmental processes. Function in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth. Involved in the differentiation of the proximal uretic smooth muscle cells during developmental processes. Involved in the up- regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter. Belongs to the teashirt C2H2-type zinc-finger protein family.
Protein type: C2H2-type zinc finger protein; Transcription factor; DNA-binding
Chromosomal Location of Human Ortholog: 19q12
Cellular Component: nucleoplasm; growth cone; mitochondrion; nucleus
Molecular Function: protein binding; DNA binding; metal ion binding; chromatin binding
Biological Process: transcription, DNA-dependent; in utero embryonic development; positive regulation of smooth muscle cell differentiation; ureteric bud development; sensory perception of touch; neurological control of breathing; negative regulation of transcription, DNA-dependent; musculoskeletal movement; metanephros development; lung development
Research Articles on TSHZ3
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Products associated with TSHZ3 blocking peptide
Diseases associated with TSHZ3 blocking peptide
Organs/Tissues associated with TSHZ3 blocking peptide
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