NP_612199.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
31,213 Da
NCBI Official Full Name
2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
NCBI Official Synonym Full Names
aminocarboxymuconate semialdehyde decarboxylase
NCBI Protein Information
2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; picolinate carboxylase
UniProt Protein Name
2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
UniProt Synonym Protein Names
Picolinate carboxylase
UniProt Entry Name
ACMSD_HUMAN
NCBI Summary for ACMSD
The neuronal excitotoxin quinolinate is an intermediate in the de novo synthesis pathway of NAD from tryptophan, and has been implicated in the pathogenesis of several neurodegenerative disorders. Quinolinate is derived from alpha-amino-beta-carboxy-muconate-epsilon-semialdehyde (ACMS). ACMSD (ACMS decarboxylase; EC 4.1.1.45) can divert ACMS to a benign catabolite and thus prevent the accumulation of quinolinate from ACMS.[supplied by OMIM, Oct 2004]
UniProt Comments for ACMSD
ACMSD: Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway. Belongs to the ACMSD family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Lyase; Amino Acid Metabolism - tryptophan; EC 4.1.1.45
Chromosomal Location of Human Ortholog: 2q21.3
Cellular Component: cytosol
Molecular Function: aminocarboxymuconate-semialdehyde decarboxylase activity; metal ion binding
Biological Process: quinolinate metabolic process; tryptophan catabolic process
Research Articles on ACMSD
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Products associated with ACMSD elisa kit
Pathways associated with ACMSD elisa kit
Diseases associated with ACMSD elisa kit
Organs/Tissues associated with ACMSD elisa kit
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