NP_006494.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
43,508 Da
NCBI Official Full Name
26S protease regulatory subunit 6B isoform 1
NCBI Official Synonym Full Names
proteasome (prosome, macropain) 26S subunit, ATPase, 4
NCBI Protein Information
26S protease regulatory subunit 6B; Tat-binding protein 7; protease 26S subunit 6; MB67-interacting protein; 26S proteasome AAA-ATPase subunit RPT3
UniProt Protein Name
26S protease regulatory subunit 6B
UniProt Synonym Protein Names
26S proteasome AAA-ATPase subunit RPT3; MB67-interacting protein; MIP224; Proteasome 26S subunit ATPase 4; Tat-binding protein 7; TBP-7
UniProt Synonym Gene Names
UniProt Entry Name
PRS6B_HUMAN
NCBI Summary for PSMC4
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the triple-A family of ATPases that is a component of the 19S regulatory subunit and plays a role in 26S proteasome assembly. The encoded protein interacts with gankyrin, a liver oncoprotein, and may also play a role in Parkinson's disease through interactions with synphilin-1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
UniProt Comments for PSMC4
RPT3: an ATPase subunit of the 26S proteasome. A member of the triple-A family of ATPases which have a chaperone-like activity. Interacts with an orphan member of the nuclear hormone receptor superfamily highly expressed in liver, and with gankyrin, a liver oncoprotein. The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Two splice variant isoforms have been described.
Protein type: Protease; Proteasome complex; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 19q13.11-q13.13
Cellular Component: proteasome complex; nucleoplasm; membrane; cytoplasm; inclusion body; nucleus; cytosol
Molecular Function: protein binding; ATPase activity; ATP binding
Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; blastocyst development; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; protein polyubiquitination; viral reproduction; apoptosis; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; proteolysis; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; regulation of apoptosis; antigen processing and presentation of peptide antigen via MHC class I; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; gene expression; mitotic cell cycle; regulation of amino acid metabolic process; negative regulation of apoptosis; G1/S transition of mitotic cell cycle
Research Articles on PSMC4
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Products associated with PSMC4 elisa kit
Pathways associated with PSMC4 elisa kit
Diseases associated with PSMC4 elisa kit
Organs/Tissues associated with PSMC4 elisa kit
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