AAB37758.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
47,402 Da
NCBI Official Full Name
growth hormone releasing hormone, partial
NCBI Official Synonym Full Names
growth hormone releasing hormone receptor
NCBI Protein Information
growth hormone-releasing hormone receptor; GRF receptor; GHRH receptor
UniProt Protein Name
Growth hormone-releasing hormone receptor
UniProt Synonym Protein Names
Growth hormone-releasing factor receptor; GRF receptor; GRFR
UniProt Synonym Gene Names
UniProt Entry Name
GHRHR_HUMAN
NCBI Summary for GHRH
This gene encodes a receptor for growth hormone-releasing hormone. Binding of this hormone to the receptor leads to synthesis and release of growth hormone. Mutations in this gene have been associated with isolated growth hormone deficiency (IGHD), also known as Dwarfism of Sindh, a disorder characterized by short stature. [provided by RefSeq, Jun 2010]
UniProt Comments for GHRH
GHRHR: Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion. Defects in GHRHR are a cause of growth hormone deficiency isolated type 1B (IGHD1B); also known as dwarfism of Sindh. IGHD1B is an autosomal recessive deficiency of GH which causes short stature. IGHD1B patients have low but detectable levels of GH. Belongs to the G-protein coupled receptor 2 family.
Protein type: GPCR, family 2; Receptor, GPCR; Cell development/differentiation; Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 7p14
Cellular Component: nuclear outer membrane; nuclear matrix; cell surface; cytoplasm; integral to membrane; plasma membrane; nuclear inner membrane; secretory granule
Molecular Function: G-protein coupled receptor activity; protein binding; peptide hormone binding; growth factor binding; growth hormone-releasing hormone receptor activity
Biological Process: positive regulation of insulin-like growth factor receptor signaling pathway; lactation; regulation of protein metabolic process; adenylate cyclase activation; cell maturation; response to glucocorticoid stimulus; positive regulation of multicellular organism growth; determination of adult life span; reproductive process in a multicellular organism; G-protein signaling, adenylate cyclase activating pathway; response to insulin stimulus; positive regulation of growth hormone secretion; water homeostasis; growth hormone secretion; cAMP-mediated signaling; cellular response to insulin stimulus; response to estrogen stimulus; positive regulation of cell proliferation; somatotropin secreting cell development; positive regulation of cAMP biosynthetic process; hormone metabolic process; regulation of steroid hormone receptor signaling pathway
Disease: Isolated Growth Hormone Deficiency, Type Ib
Research Articles on GHRH
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Pathways associated with GHRH elisa kit
Diseases associated with GHRH elisa kit
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