NP_000520.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
33,927 Da
NCBI Official Full Name
adrenocorticotropic hormone receptor
NCBI Official Synonym Full Names
melanocortin 2 receptor (adrenocorticotropic hormone)
NCBI Official Synonym Symbols
NCBI Protein Information
adrenocorticotropic hormone receptor; MC2 receptor; ACTH receptor; corticotropin receptor; adrenocorticotropin receptor
UniProt Protein Name
Adrenocorticotropic hormone receptor
UniProt Synonym Protein Names
Adrenocorticotropin receptor; Melanocortin receptor 2
UniProt Synonym Gene Names
UniProt Entry Name
ACTHR_HUMAN
NCBI Summary for ACTHR
MC2R encodes one member of the five-member G-protein associated melanocortin receptor family. Melanocortins (melanocyte-stimulating hormones and adrenocorticotropic hormone) are peptides derived from pro-opiomelanocortin (POMC). MC2R is selectively activated by adrenocorticotropic hormone, whereas the other four melanocortin receptors recognize a variety of melanocortin ligands. Mutations in MC2R can result in familial glucocorticoid deficiency. [provided by RefSeq, Jul 2008]
UniProt Comments for ACTHR
MC2R: Receptor for ACTH. This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase. Defects in MC2R are the cause of glucocorticoid deficiency type 1 (GCCD1); also known as familial glucocorticoid deficiency type 1 (FGD1). GCCD1 is an autosomal recessive disorder due to congenital insensitivity or resistance to adrenocorticotropin (ACTH). It is characterized by progressive primary adrenal insufficiency, without mineralocorticoid deficiency. Belongs to the G-protein coupled receptor 1 family.
Protein type: GPCR, family 1; Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 18p11.2
Cellular Component: integral to plasma membrane; cytoplasm; plasma membrane
Molecular Function: protein binding; melanocortin receptor activity; adrenocorticotropin receptor activity
Biological Process: G-protein signaling, coupled to cyclic nucleotide second messenger; G-protein coupled receptor protein signaling pathway; neuropeptide signaling pathway; positive regulation of cAMP biosynthetic process; placenta development
Disease: Glucocorticoid Deficiency 1
Research Articles on ACTHR
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Products associated with ACTHR elisa kit
Pathways associated with ACTHR elisa kit
Diseases associated with ACTHR elisa kit
Organs/Tissues associated with ACTHR elisa kit
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