NP_001275537.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
118,822 Da
NCBI Official Full Name
ADAMTS-like protein 4 isoform 4
NCBI Official Synonym Full Names
ADAMTS-like 4
NCBI Protein Information
ADAMTS-like protein 4; thrombospondin repeat-containing protein 1
UniProt Protein Name
ADAMTS-like protein 4
UniProt Synonym Protein Names
Thrombospondin repeat-containing protein 1
UniProt Synonym Gene Names
UniProt Entry Name
ATL4_HUMAN
NCBI Summary for ADAMTSL4
This gene is a member of ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs)-like gene family and encodes a protein with seven thrombospondin type 1 repeats. The thrombospondin type 1 repeat domain is found in many proteins with diverse biological functions including cellular adhesion, angiogenesis, and patterning of the developing nervous system. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Sep 2014]
UniProt Comments for ADAMTSL4
TSRC1: Positive regulation of apoptosis. May facilitate FBN1 microfibril biogenesis. Defects in ADAMTSL4 are a cause of autosomal recessive isolated ectopia lentis (ARI-EL). ARI-EL is a rare condition characterized by partial or complete displacement of the lens from its space resulting from defective zonule formation. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 1q21.3
Cellular Component: endoplasmic reticulum lumen
Molecular Function: protein binding; protease binding; metalloendopeptidase activity
Biological Process: protein amino acid O-linked glycosylation; extracellular matrix organization and biogenesis; cellular protein metabolic process; positive regulation of apoptosis; apoptosis; proteolysis; post-translational protein modification
Disease: Ectopia Lentis 2, Isolated, Autosomal Recessive; Ectopia Lentis Et Pupillae
Research Articles on ADAMTSL4
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Pathways associated with ADAMTSL4 elisa kit
Diseases associated with ADAMTSL4 elisa kit
Organs/Tissues associated with ADAMTSL4 elisa kit
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