NP_066998.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
9,408 Da
NCBI Official Full Name
hepcidin preproprotein
NCBI Official Synonym Full Names
hepcidin antimicrobial peptide
NCBI Protein Information
hepcidin; putative liver tumor regressor; liver-expressed antimicrobial peptide 1
UniProt Protein Name
Hepcidin
UniProt Synonym Protein Names
Liver-expressed antimicrobial peptide 1; LEAP-1; Putative liver tumor regressor; PLTR
UniProt Synonym Gene Names
UniProt Entry Name
HEPC_HUMAN
NCBI Summary for Hepc25
The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease caused by severe iron overload that results in cardiomyopathy, cirrhosis, and endocrine failure. [provided by RefSeq, Jul 2008]
UniProt Comments for Hepc25
HAMP: Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages. Defects in HAMP are the cause of hemochromatosis type 2B (HFE2B); also known as juvenile hemochromatosis (JH). HFE2B is a disorder of iron metabolism with excess deposition of iron in the tissues, bronze skin pigmentation, hepatic cirrhosis, arthropathy and diabetes. The most common symptoms of hemochromatosis type 2 at presentation are hypogonadism and cardiomyopathy. Belongs to the hepcidin family.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 19q13.1
Cellular Component: apical cortex; extracellular region
Molecular Function: hormone activity
Biological Process: killing of cells of another organism; cellular iron ion homeostasis; defense response to bacterium; immune response; defense response to fungus
Disease: Hemochromatosis, Type 2b
Research Articles on Hepc25
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Products associated with Hepc25 elisa kit
Pathways associated with Hepc25 elisa kit
Diseases associated with Hepc25 elisa kit
Organs/Tissues associated with Hepc25 elisa kit
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