NP_055982.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
47,626 Da
NCBI Official Full Name
bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 isoform 2
NCBI Official Synonym Full Names
jumonji domain containing 6
NCBI Protein Information
bifunctional arginine demethylase and lysyl-hydroxylase JMJD6; phosphatidylserine receptor; jmjC domain-containing protein 6; histone arginine demethylase JMJD6; peptide-lysine 5-dioxygenase JMJD6; jumonji domain-containing protein 6
UniProt Protein Name
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
UniProt Synonym Protein Names
Histone arginine demethylase JMJD6; JmjC domain-containing protein 6; Jumonji domain-containing protein 6; Lysyl-hydroxylase JMJD6; Peptide-lysine 5-dioxygenase JMJD6; Phosphatidylserine receptor; Protein PTDSR
UniProt Synonym Gene Names
UniProt Entry Name
JMJD6_HUMAN
NCBI Summary for JMJD6
This gene encodes a nuclear protein with a JmjC domain. JmjC domain-containing proteins are predicted to function as protein hydroxylases or histone demethylases. This protein was first identified as a putative phosphatidylserine receptor involved in phagocytosis of apoptotic cells; however, subsequent studies have indicated that it does not directly function in the clearance of apoptotic cells, and questioned whether it is a true phosphatidylserine receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for JMJD6
JMJD6: Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Acts as a regulator of RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. In addition to peptidyl-lysine 5-dioxygenase activity, may act as a RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an arginine demethylase which demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), thereby playing a role in histone code. However, histone arginine demethylation may not constitute the primary activity in vivo. Has no histone lysine demethylase activity. Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation: required for angiogenic sprouting by regulating the pre-mRNA splicing activity of U2AF2/U2AF65. Seems to be necessary for the regulation of macrophage cytokine responses. Belongs to the JMJD6 family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell development/differentiation; Receptor, misc.; EC 1.14.11.-; Nucleolus; Oxidoreductase; Apoptosis
Chromosomal Location of Human Ortholog: 17q25
Cellular Component: nucleoplasm; plasma membrane; nucleolus; nucleus
Molecular Function: identical protein binding; protein binding; single-stranded RNA binding; histone demethylase activity (H4-R3 specific); RNA binding; iron ion binding; receptor activity; histone demethylase activity (H3-R2 specific)
Biological Process: erythrocyte development; transcription, DNA-dependent; RNA splicing; heart development; T cell differentiation in the thymus; recognition of apoptotic cell; peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine; macrophage activation; regulation of nuclear mRNA splicing, via spliceosome; cell surface receptor linked signal transduction; regulation of transcription, DNA-dependent; retina development in camera-type eye; sprouting angiogenesis; mRNA processing; kidney development; lung development
Research Articles on JMJD6
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Diseases associated with JMJD6 elisa kit
Organs/Tissues associated with JMJD6 elisa kit
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