AAA34780.1
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UniProt Secondary Accession #
Molecular Weight
21,499 Da
NCBI Official Full Name
O-6-methylguanine-DNA methyltransferase
UniProt Protein Name
Methylated-DNA--protein-cysteine methyltransferase
UniProt Synonym Protein Names
6-O-methylguanine-DNA methyltransferase; MGMT; DNA repair MTase; O-6-methylguanine-DNA-alkyltransferase
UniProt Synonym Gene Names
UniProt Entry Name
MGMT_YEAST
UniProt Comments for MGMP
Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. Also repairs O-4-methylthymine. Prefers double-stranded DNA over single-stranded DNA as substrate.
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