NP_001012147.1
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NCBI GenBank Nucleotide #
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UniProt Related Accession #
Molecular Weight
64,019 Da
NCBI Official Full Name
paxillin
NCBI Official Synonym Full Names
paxillin
NCBI Protein Information
paxillin; myocardial ischemic preconditioning associated protein 7
UniProt Protein Name
Paxillin
UniProt Entry Name
PAXI_RAT
UniProt Comments for Pax
PXN: a multi-domain cytoskeletal protein involved in actin-membrane attachment that localizes primarily to focal adhesion sites to the extracellular matrix. Phosphorylated by focal adhesion kinase (FAK) and is a component of integrin signaling. Its phosphorylation provides docking sites for recruitment of signaling molecules to focal adhesions. Binds in vitro to vinculin as well as to the SH3 domain of c-SRC and, when tyrosine phosphorylated, to the Crk SH2 domain. Interacts with GIT1, NUDT16L1/SDOS, PARVA and TGFB1I1. Component of cytoplasmic complexes, which also contain GIT1, ARHGEF6 and PAK1. Binds DDEF2. Interacts with unphosphorylated ITGA4. Interacts with RNF5.Three alternatively-spliced isoforms have been described. Isoform beta binds to focal adhesion kinase but weakly to vinculin. Isoform gamma binds to vinculin but only weakly to focal adhesion kinase.
Protein type: Cell adhesion; Adaptor/scaffold; Motility/polarity/chemotaxis; Cytoskeletal
Cellular Component: nucleoplasm; cytoskeleton; focal adhesion; lamellipodium; cytoplasm; leading edge; plasma membrane; stress fiber; cell cortex; nucleus
Molecular Function: integrin binding; zinc ion binding; beta-catenin binding; protein complex binding; BH4 domain binding; protein kinase binding; vinculin binding
Biological Process: focal adhesion formation; integrin-mediated signaling pathway; lamellipodium biogenesis; regulation of cell shape; peptidyl-tyrosine phosphorylation; branching morphogenesis of a tube; activation of MAPK activity; cell-matrix adhesion; positive regulation of protein kinase activity; transforming growth factor beta receptor signaling pathway; cytoskeleton organization and biogenesis
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Pathways associated with Pax elisa kit
Diseases associated with Pax elisa kit
Organs/Tissues associated with Pax elisa kit
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