NP_077816.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
167,688 Da
NCBI Official Full Name
probable phospholipid-transporting ATPase VA
NCBI Official Synonym Full Names
ATPase, class V, type 10A
NCBI Protein Information
probable phospholipid-transporting ATPase VA; ATPase, Class V, type 10C; aminophospholipid translocase VA; P4-ATPase flippase complex alpha subunit ATP10A; ATPase type IV, phospholipid transporting (P-type)
UniProt Protein Name
Probable phospholipid-transporting ATPase VA
UniProt Synonym Protein Names
ATPase class V type 10A; Aminophospholipid translocase VA; P4-ATPase flippase complex alpha subunit ATP10A
UniProt Synonym Gene Names
UniProt Entry Name
AT10A_HUMAN
NCBI Summary for ATP10A
The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of aminophospholipid-transporting ATPases. The aminophospholipid translocases transport phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to another. This gene is maternally expressed. It maps within the most common interval of deletion responsible for Angelman syndrome, also known as 'happy puppet syndrome'. [provided by RefSeq, Jul 2008]
UniProt Comments for ATP10A
ATP10A: Defects in ATP10A are a cause of Angelman syndrome (AS); also known as 'happy puppet syndrome'. AS is characterized by features of severe motor and intellectual retardation, microcephaly, ataxia, frequent jerky limb movements and flapping of the arms and hands, hypotonia, hyperactivity, hypopigmentation, seizures, absence of speech, frequent smiling and episodes of paroxysmal laughter, and an unusual facies characterized by macrostomia, a large mandible and open-mouthed expression, a great propensity for protruding the tongue ('tongue thrusting'), and an occipital groove. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
Protein type: Membrane protein, integral; Hydrolase; Membrane protein, multi-pass; EC 3.6.3.1; Transporter, ion channel; Transporter
Chromosomal Location of Human Ortholog: 15q11.2
Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum; integral to membrane; plasma membrane
Molecular Function: phospholipid-translocating ATPase activity; protein binding; magnesium ion binding; ATP binding
Biological Process: phospholipid translocation; regulation of cell shape; intracellular protein transport; metabolic process; transmembrane transport
Research Articles on ATP10A
Precautions
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Pathways associated with ATP10A elisa kit
Diseases associated with ATP10A elisa kit
Organs/Tissues associated with ATP10A elisa kit
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