EAX01706.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
18,835 Da
NCBI Official Full Name
adenylate cyclase activating polypeptide 1 (pituitary)
NCBI Official Synonym Full Names
adenylate cyclase activating polypeptide 1 (pituitary)
NCBI Official Synonym Symbols
NCBI Protein Information
pituitary adenylate cyclase-activating polypeptide; prepro-PACAP
UniProt Protein Name
Pituitary adenylate cyclase-activating polypeptide
UniProt Synonym Protein Names
PRP-48
UniProt Synonym Gene Names
UniProt Entry Name
PACA_HUMAN
NCBI Summary for ADCYAP1
This gene encodes a secreted proprotein that is further processed into multiple mature peptides. These peptides stimulate adenylate cyclase and increase cyclic adenosine monophosphate (cAMP) levels, resulting in the transcriptional activation of target genes. The products of this gene are key mediators of neuroendocrine stress responses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013]
UniProt Comments for ADCYAP1
ADCYAP1: Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells. Belongs to the glucagon family.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 18p11
Cellular Component: extracellular space; extracellular region; terminal button
Molecular Function: neuropeptide hormone activity; peptide hormone receptor binding; receptor signaling protein activity; pituitary adenylate cyclase-activating peptide receptor binding; pituitary adenylate cyclase activating polypeptide activity; receptor binding
Biological Process: behavioral fear response; nerve growth factor receptor signaling pathway; negative regulation of potassium ion transport; female pregnancy; sensory perception of pain; positive regulation of vasodilation; positive regulation of synaptic transmission, glutamatergic; negative regulation of cell cycle; histamine secretion; cAMP-mediated signaling; elevation of cytosolic calcium ion concentration; regulation of protein localization; ovarian follicle development; cell-cell signaling; neuropeptide signaling pathway; positive regulation of cell proliferation; neurite development; negative regulation of acute inflammatory response to antigenic stimulus; adenylate cyclase activation; positive regulation of interleukin-6 production; positive regulation of growth hormone secretion; response to starvation; ATP metabolic process; regulation of postsynaptic membrane potential; response to ethanol; pituitary gland development; positive regulation of protein kinase activity; positive regulation of transcription from RNA polymerase II promoter; negative regulation of acute inflammatory response to non-antigenic stimulus; transmembrane receptor protein tyrosine kinase signaling pathway; regulation of G-protein coupled receptor protein signaling pathway
Research Articles on ADCYAP1
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Products associated with ADCYAP1 elisa kit
Pathways associated with ADCYAP1 elisa kit
Diseases associated with ADCYAP1 elisa kit
Organs/Tissues associated with ADCYAP1 elisa kit
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