CAG46950.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
14,748 Da
NCBI Official Full Name
AIF1, partial
NCBI Official Synonym Full Names
allograft inflammatory factor 1
NCBI Protein Information
allograft inflammatory factor 1; protein G1; interferon gamma responsive transcript; ionized calcium-binding adapter molecule 1; allograft inflammatory factor-1 splice variant Hara-1
UniProt Protein Name
Allograft inflammatory factor 1
UniProt Synonym Protein Names
Ionized calcium-binding adapter molecule 1; Protein G1
UniProt Synonym Gene Names
UniProt Entry Name
AIF1_HUMAN
NCBI Summary for AIF1
This gene is induced by cytokines and interferon. Its protein product is thought to be involved in negative regulation of growth of vascular smooth muscle cells, which contributes to the anti-inflammatory response to vessel wall trauma. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
UniProt Comments for AIF1
AIF1: Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T- lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 6p21.3
Cellular Component: lamellipodium; perinuclear region of cytoplasm; cytoplasm; perikaryon; actin filament; nucleus; cytosol; phagocytic cup
Molecular Function: actin filament binding; calcium ion binding
Biological Process: actin filament bundle formation; positive regulation of nitric oxide biosynthetic process; negative regulation of smooth muscle cell proliferation; positive regulation of smooth muscle cell proliferation; Rac protein signal transduction; microglial cell activation; cellular response to hormone stimulus; actin filament polymerization; positive regulation of muscle hyperplasia; cellular response to extracellular stimulus; positive regulation of T cell proliferation; positive regulation of protein amino acid phosphorylation; response to axon injury; response to electrical stimulus; inflammatory response; phagocytosis, engulfment; negative regulation of apoptosis
Research Articles on AIF1
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Products associated with AIF1 elisa kit
Pathways associated with AIF1 elisa kit
Diseases associated with AIF1 elisa kit
Organs/Tissues associated with AIF1 elisa kit
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