BAH36764.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
51,306 Da
NCBI Official Full Name
bisphenol A receptor ERRgamma2
NCBI Official Synonym Full Names
estrogen-related receptor gamma
NCBI Protein Information
estrogen-related receptor gamma; ERR gamma-2; estrogen receptor-related protein 3; nuclear receptor subfamily 3 group B member 3
UniProt Protein Name
Estrogen-related receptor gamma
UniProt Synonym Protein Names
ERR gamma-2; Estrogen receptor-related protein 3; Nuclear receptor subfamily 3 group B member 3
UniProt Synonym Gene Names
UniProt Entry Name
ERR3_HUMAN
NCBI Summary for BPA
This gene encodes a member of the estrogen receptor-related receptor (ESRR) family, which belongs to the nuclear hormone receptor superfamily. All members of the ESRR family share an almost identical DNA binding domain, which is composed of two C4-type zinc finger motifs. The ESRR members are orphan nuclear receptors; they bind to the estrogen response element and steroidogenic factor 1 response element, and activate genes controlled by both response elements in the absence of any ligands. The ESRR family is closely related to the estrogen receptor (ER) family. They share target genes, co-regulators and promoters, and by targeting the same set of genes, the ESRRs seem to interfere with the ER-mediated estrogen response in various ways. It has been reported that the family member encoded by this gene functions as a transcriptional activator of DNA cytosine-5-methyltransferases 1 (Dnmt1) expression by direct binding to its response elements in the DNMT1 promoters, modulates cell proliferation and estrogen signaling in breast cancer, and negatively regulates bone morphogenetic protein 2-induced osteoblast differentiation and bone formation. Multiple alternatively spliced transcript variants have been identified, which mainly differ at the 5' end and some of which encode protein isoforms differing in the N-terminal region. [provided by RefSeq, Aug 2011]
UniProt Comments for BPA
ERR3: Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements. Belongs to the nuclear hormone receptor family. NR3 subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA-binding; Transcription factor; Nuclear receptor
Chromosomal Location of Human Ortholog: 1q41
Cellular Component: nucleoplasm
Molecular Function: protein binding; zinc ion binding; AF-2 domain binding; steroid hormone receptor activity; retinoic acid receptor activity; steroid binding
Biological Process: retinoic acid receptor signaling pathway; transcription initiation from RNA polymerase II promoter; regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; steroid hormone mediated signaling; gene expression; positive regulation of transcription from RNA polymerase II promoter
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Pathways associated with BPA elisa kit
Diseases associated with BPA elisa kit
Organs/Tissues associated with BPA elisa kit
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