NP_055236.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
28,447 Da
NCBI Official Full Name
dickkopf-related protein 2
NCBI Official Synonym Full Names
dickkopf WNT signaling pathway inhibitor 2
NCBI Official Synonym Symbols
NCBI Protein Information
dickkopf-related protein 2; dickkopf 2 homolog; dickkopf homolog 2; dickkopf related protein-2; dickkopf-2; hDkk-2
UniProt Protein Name
Dickkopf-related protein 2
UniProt Synonym Gene Names
UniProt Entry Name
DKK2_HUMAN
NCBI Summary for DKK2
This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6). [provided by RefSeq, Jul 2008]
UniProt Comments for DKK2
DKK2: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Interacts with LRP5 and LRP6. Expressed in heart, brain, skeletal muscle and lung. Belongs to the dickkopf family.
Protein type: Inhibitor; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 4q25
Cellular Component: extracellular space
Biological Process: Wnt receptor signaling pathway; multicellular organismal development
Research Articles on DKK2
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Products associated with DKK2 elisa kit
Pathways associated with DKK2 elisa kit
Diseases associated with DKK2 elisa kit
Organs/Tissues associated with DKK2 elisa kit
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