NP_788785.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
24,908 Da
NCBI Official Full Name
high mobility group protein B1
NCBI Official Synonym Full Names
high mobility group box 1<
NCBI Protein Information
high mobility group protein B1; HMG-1; high mobility group protein 1; high-mobility group box 1
UniProt Protein Name
High mobility group protein B1
UniProt Synonym Protein Names
High mobility group protein 1; HMG-1
UniProt Synonym Gene Names
UniProt Entry Name
HMGB1_BOVIN
UniProt Comments for HMGB-1
HMGB1: DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells. Component of the RAG complex composed of core components RAG1 and RAG2, and associated component HMGB1 or HMGB2. Belongs to the HMGB family.
Protein type: Nuclear receptor co-regulator; DNA repair, damage
Cellular Component: extracellular space; cell surface; transcriptional repressor complex; condensed chromosome; nucleus
Molecular Function: histone binding; double-stranded DNA binding; damaged DNA binding; chromatin binding; DNA bending activity; transcription factor activity; single-stranded DNA binding; chemoattractant activity
Biological Process: negative regulation of transcriptional preinitiation complex assembly; V(D)J recombination; DNA topological change; positive regulation of caspase activity; base-excision repair, DNA ligation; DNA recombination; regulation of transcription from RNA polymerase II promoter; chromatin remodeling; myeloid dendritic cell activation; inflammatory response to antigenic stimulus; positive chemotaxis; regulation of transcription, DNA-dependent; dendritic cell chemotaxis; positive regulation of transcription from RNA polymerase II promoter; positive regulation of DNA binding
Research Articles on HMGB-1
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Products associated with HMGB-1 elisa kit
Pathways associated with HMGB-1 elisa kit
Diseases associated with HMGB-1 elisa kit
Organs/Tissues associated with HMGB-1 elisa kit
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