NP_005348.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
84,128 Da
NCBI Official Full Name
hormone-sensitive lipase
NCBI Official Synonym Full Names
lipase, hormone-sensitive
NCBI Protein Information
hormone-sensitive lipase; hormone-sensitive lipase testicular isoform
UniProt Protein Name
Hormone-sensitive lipase
UniProt Synonym Gene Names
UniProt Entry Name
LIPS_HUMAN
NCBI Summary for HSL
The protein encoded by this gene has a long and a short form, generated by use of alternative translational start codons. The long form is expressed in steroidogenic tissues such as testis, where it converts cholesteryl esters to free cholesterol for steroid hormone production. The short form is expressed in adipose tissue, among others, where it hydrolyzes stored triglycerides to free fatty acids. [provided by RefSeq, Jul 2008]
UniProt Comments for HSL
HSL: hormone sensitive lipase is a lipolytic enzyme of the 'GDXG' family. Plays a rate limiting step in triglyceride lipolysis. In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production. Rapidly activated by cAMP-dependent phosphorylation under the influence of catecholamines. Dephosphorylation and inactivation are controlled by insulin.
Protein type: Lipase; EC 3.1.1.79
Chromosomal Location of Human Ortholog: 19q13.2
Cellular Component: lipid particle; caveola; cytosol
Molecular Function: hormone-sensitive lipase activity; triacylglycerol lipase activity; protein binding; protein kinase binding
Biological Process: cholesterol metabolic process; triacylglycerol catabolic process; diacylglycerol catabolic process; protein amino acid phosphorylation; lipid catabolic process; long-chain fatty acid catabolic process
Disease: Abdominal Obesity-metabolic Syndrome 4
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Products associated with HSL elisa kit
Pathways associated with HSL elisa kit
Diseases associated with HSL elisa kit
Organs/Tissues associated with HSL elisa kit
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