NP_003740.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
137,334 Da
NCBI Official Full Name
insulin receptor substrate 2
NCBI Official Synonym Full Names
insulin receptor substrate 2
NCBI Official Synonym Symbols
NCBI Protein Information
insulin receptor substrate 2
UniProt Protein Name
Insulin receptor substrate 2
UniProt Synonym Gene Names
UniProt Entry Name
IRS2_HUMAN
NCBI Summary for IRS-2
This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment. [provided by RefSeq, Jul 2008]
UniProt Comments for IRS-2
IRS2: May mediate the control of various cellular processes by insulin. Interacts with PHIP.
Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold
Chromosomal Location of Human Ortholog: 13q34
Cellular Component: plasma membrane; cytosol
Molecular Function: protein domain specific binding; signal transducer activity; protein binding; phosphoinositide 3-kinase binding; protein phosphatase binding; protein kinase binding; insulin receptor binding
Biological Process: negative regulation of kinase activity; regulation of lipid metabolic process; nerve growth factor receptor signaling pathway; positive regulation of glycogen biosynthetic process; lipid homeostasis; signal transduction; positive regulation of glucose import; mammary gland development; positive regulation of cell proliferation; positive regulation of mesenchymal cell proliferation; positive regulation of B cell proliferation; response to glucose stimulus; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; positive regulation of insulin secretion; glucose metabolic process; positive regulation of fatty acid beta-oxidation; cell proliferation; cellular response to insulin stimulus; insulin receptor signaling pathway; innate immune response; brain development; negative regulation of B cell apoptosis; positive regulation of cell migration
Disease: Diabetes Mellitus, Noninsulin-dependent
Research Articles on IRS-2
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Products associated with IRS-2 elisa kit
Pathways associated with IRS-2 elisa kit
Diseases associated with IRS-2 elisa kit
Organs/Tissues associated with IRS-2 elisa kit
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