NP_001243805.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
147,289 Da
NCBI Official Full Name
KN motif and ankyrin repeat domain-containing protein 1 isoform a
NCBI Official Synonym Full Names
KN motif and ankyrin repeat domains 1
NCBI Protein Information
KN motif and ankyrin repeat domain-containing protein 1; kidney ankyrin repeat-containing protein; ankyrin repeat domain-containing protein 15
UniProt Protein Name
KN motif and ankyrin repeat domain-containing protein 1
UniProt Synonym Protein Names
Ankyrin repeat domain-containing protein 15; Kidney ankyrin repeat-containing protein
UniProt Synonym Gene Names
UniProt Entry Name
KANK1_HUMAN
NCBI Summary for KANK1
The protein encoded by this gene belongs to the Kank family of proteins, which contain multiple ankyrin repeat domains. This family member functions in cytoskeleton formation by regulating actin polymerization. This gene is a candidate tumor suppressor for renal cell carcinoma. Mutations in this gene cause cerebral palsy spastic quadriplegic type 2, a central nervous system development disorder. A t(5;9) translocation results in fusion of the platelet-derived growth factor receptor beta gene (PDGFRB) on chromosome 5 with this gene in a myeloproliferative neoplasm featuring severe thrombocythemia. Alternative splicing of this gene results in multiple transcript variants. A related pseuodgene has been identified on chromosome 20. [provided by RefSeq, Mar 2012]
UniProt Comments for KANK1
ANKRD15: Involved in the control of cytoskeleton formation by regulating actin polymerization. Inhibits actin fiber formation and cell migration. Inhibits RhoA activity; the function involves phosphorylation through PI3K/Akt signaling and may depend on the competetive interaction with 14-3-3 adapter proteins to sequester them from active complexes. Inhibits the formation of lamellipodia but not of filopodia; the function may depend on the competetive interaction with BAIAP2 to block its association with activated RAC1. Inhibits fibronectin-mediated cell spreading; the function is partially mediated by BAIAP2. Inhibits neurite outgrowth. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. In the nucleus, is involved in beta-catenin-dependent activation of transcription. Potential tumor suppressor for renal cell carcinoma. Defects in KANK1 are the cause of cerebral palsy spastic quadriplegic type 2 (CPSQ2). A non-progressive disorder of movement and/or posture resulting from defects in the developing central nervous system. Affected individuals manifest congenital hypotonia evolving over the first year to spastic quadriplegia with accompanying transient nystagmus and varying degrees of mental retardation. Neuroimaging shows brain atrophy and ventriculomegaly. 2 isoforms of the human protein are produced by alternative promoter.
Protein type: Tumor suppressor
Chromosomal Location of Human Ortholog: 9p24.3
Cellular Component: cytoplasm; nucleus
Molecular Function: protein binding; beta-catenin binding
Biological Process: negative regulation of Rho protein signal transduction; transcription, DNA-dependent; regulation of transcription, DNA-dependent; negative regulation of actin filament polymerization; negative regulation of insulin receptor signaling pathway; negative regulation of cell migration; positive regulation of Wnt receptor signaling pathway
Disease: Cerebral Palsy, Spastic Quadriplegic, 2
Research Articles on KANK1
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Diseases associated with KANK1 elisa kit
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