AAD21822.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
92,875 Da
NCBI Official Full Name
MutSH5
NCBI Official Synonym Full Names
mutS homolog 5
NCBI Protein Information
mutS protein homolog 5
UniProt Protein Name
MutS protein homolog 5
UniProt Synonym Gene Names
UniProt Entry Name
MSH5_HUMAN
NCBI Summary for MHC 3
This gene encodes a member of the mutS family of proteins that are involved in DNA mismatch repair and meiotic recombination. This protein is similar to a Saccharomyces cerevisiae protein that participates in segregation fidelity and crossing-over events during meiosis. This protein plays a role in promoting ionizing radiation-induced apoptosis. This protein forms hetero-oligomers with another member of this family, mutS homolog 4. Polymorphisms in this gene have been linked to various human diseases, including IgA deficiency, common variable immunodeficiency, and premature ovarian failure. Alternative splicing results multiple transcript variants. Read-through transcription also exists between this gene and the downstream chromosome 6 open reading frame 26 (C6orf26) gene. [provided by RefSeq, Feb 2011]
UniProt Comments for MHC 3
MSH5: Involved in meiotic recombination. Facilitate crossovers between homologs during meiosis. Belongs to the DNA mismatch repair MutS family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 6p21.3
Cellular Component: synaptonemal complex
Molecular Function: DNA-dependent ATPase activity; protein binding; damaged DNA binding; ATP binding; mismatched DNA binding
Biological Process: homologous chromosome segregation; meiotic recombination; chiasma formation; meiotic mismatch repair
Research Articles on MHC 3
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Products associated with MHC 3 elisa kit
Pathways associated with MHC 3 elisa kit
Diseases associated with MHC 3 elisa kit
Organs/Tissues associated with MHC 3 elisa kit
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