NP_945317.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
20,194 Da
NCBI Official Full Name
parathyroid hormone-related protein isoform 1 preproprotein
NCBI Official Synonym Full Names
parathyroid hormone-like hormone
NCBI Protein Information
parathyroid hormone-related protein; PTH-rP; osteostatin; PTH-related protein; parathyroid hormone-like related protein
UniProt Protein Name
Parathyroid hormone-related protein
UniProt Synonym Protein Names
Parathyroid hormone-like protein; PLPCleaved into the following 3 chains:PTHrP[1-36]PTHrP[38-94]Osteostatin; Alternative name(s):; PTHrP[107-139]
UniProt Synonym Gene Names
UniProt Entry Name
PTHR_HUMAN
NCBI Summary for PTHRP
The protein encoded by this gene is a member of the parathyroid hormone family. This hormone regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. This hormone is involved in lactation possibly by regulating the mobilization and transfer of calcium to the milk. The receptor of this hormone, PTHR1, is responsible for most cases of humoral hypercalcemia of malignancy. Four alternatively spliced transcript variants encoding two distinct isoforms have been observed. There is also evidence for alternative translation initiation from non-AUG (CUG and GUG) start sites, in-frame and downstream of the initiator AUG codon, to give rise to nuclear forms of this hormone. [provided by RefSeq, Jul 2008]
UniProt Comments for PTHRP
PTHrP: a member of the parathyroid hormone family. This hormone regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. This hormone is involved in lactation possibly by regulating the mobilization and transfer of calcium to the milk. The receptor of this hormone, PTHR1, is responsible for most cases of humoral hypercalcemia of malignancy. Three alternatively spliced isoforms have been described.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 12p12.1-p11.2
Cellular Component: nucleoplasm; Golgi apparatus; extracellular space; cytoplasm; extracellular region
Molecular Function: peptide hormone receptor binding; hormone activity
Biological Process: epidermis development; negative regulation of transcription factor activity; negative regulation of chondrocyte differentiation; female pregnancy; G-protein signaling, adenylate cyclase activating pathway; osteoblast development; negative regulation of cell proliferation; cAMP metabolic process; epithelial cell differentiation; cell-cell signaling; regulation of gene expression; positive regulation of cAMP biosynthetic process; positive regulation of cell proliferation; protein processing; alveolus development; skeletal development; surfactant homeostasis; endochondral ossification; endoderm development
Disease: Brachydactyly, Type E2
Research Articles on PTHRP
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Products associated with PTHRP elisa kit
Pathways associated with PTHRP elisa kit
Diseases associated with PTHRP elisa kit
Organs/Tissues associated with PTHRP elisa kit
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