CAA54669.1
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
2,342 Da
NCBI Official Full Name
tPA, partial
NCBI Official Synonym Full Names
plasminogen activator, tissue
NCBI Official Synonym Symbols
NCBI Protein Information
tissue-type plasminogen activator; alteplase; reteplase; t-plasminogen activator; plasminogen activator, tissue type; tissue plasminogen activator (t-PA)
UniProt Protein Name
TPA protein
UniProt Synonym Protein Names
TPA protein
UniProt Entry Name
Q6LBF5_HUMAN
NCBI Summary for TPA
This gene encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
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Pathways associated with TPA elisa kit
Organs/Tissues associated with TPA elisa kit
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