AAH47779.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
42,193 Da
NCBI Official Full Name
Transmembrane protein 173
NCBI Official Synonym Full Names
transmembrane protein 173
NCBI Official Synonym Symbols
ERIS; MITA; MPYS; SAVI; NET23; STING; hMITA; hSTING [Similar Products]
NCBI Protein Information
stimulator of interferon genes protein; endoplasmic reticulum IFN stimulator; mitochondrial mediator of IRF3 activation; endoplasmic reticulum interferon stimulator; N-terminal methionine-proline-tyrosine-serine plasma membrane tetraspanner
UniProt Protein Name
Stimulator of interferon genes protein
UniProt Synonym Protein Names
Endoplasmic reticulum interferon stimulator; ERIS; Mediator of IRF3 activation; hMITA; Transmembrane protein 173
UniProt Synonym Gene Names
UniProt Entry Name
STING_HUMAN
NCBI Summary for TMEM173
This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]
UniProt Comments for TMEM173
TMEM173: Facilitator of innate immune signaling that promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double- stranded DNA from viruses and bacteria delivered to the cytoplasm. Able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti- viral state following expression. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway. Associates with the MHC-II complex. Homodimer; 'Lys-63'-linked ubiquitination at Lys-150 is required for homodimerization. Interacts with DDX58/RIG-I, MAVS/VISA and SSR2. Interacts with RNF5 and TRIM56. Interacts with TBK1; when homodimer, leading to subsequent production of IFN-beta. Ubiquitously expressed. Belongs to the TMEM173 family.
Protein type: Mitochondrial; Endoplasmic reticulum; Membrane protein, integral; Apoptosis; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 5q31.2
Cellular Component: Golgi apparatus; mitochondrial outer membrane; endoplasmic reticulum membrane; cytoplasmic vesicle membrane; perinuclear region of cytoplasm; plasma membrane; integral to membrane; peroxisome
Molecular Function: identical protein binding; protein binding; protein homodimerization activity; ubiquitin protein ligase binding; transcription factor binding; protein kinase binding
Biological Process: regulation of interferon type I production; positive regulation of protein binding; positive regulation of protein import into nucleus, translocation; apoptosis; positive regulation of transcription factor import into nucleus; positive regulation of interferon type I production; innate immune response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of defense response to virus by host; activation of innate immune response; defense response to virus; interferon-beta production
Disease: Sting-associated Vasculopathy, Infantile-onset
Research Articles on TMEM173
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Products associated with TMEM173 elisa kit
Pathways associated with TMEM173 elisa kit
Diseases associated with TMEM173 elisa kit
Organs/Tissues associated with TMEM173 elisa kit
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