AAA86934.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
29,533 Da
NCBI Official Full Name
tryptase
NCBI Official Synonym Full Names
tryptase alpha/beta 1
NCBI Protein Information
tryptase alpha/beta-1
UniProt Protein Name
Tryptase alpha/beta-1
UniProt Synonym Protein Names
Tryptase I; Tryptase alpha-1
UniProt Synonym Gene Names
UniProt Entry Name
TRYB1_HUMAN
NCBI Summary for TPS
Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, alpha and beta 1. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. [provided by RefSeq, Jul 2008]
UniProt Comments for TPS
TPSAB1: Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. Belongs to the peptidase S1 family. Tryptase subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted, signal peptide; Protease; EC 3.4.21.59; Secreted
Chromosomal Location of Human Ortholog: 16p13.3
Cellular Component: extracellular matrix; extracellular space; extracellular region
Molecular Function: protein binding; serine-type peptidase activity; serine-type endopeptidase activity
Biological Process: extracellular matrix disassembly; extracellular matrix organization and biogenesis; defense response; proteolysis
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Products associated with TPS elisa kit
Pathways associated with TPS elisa kit
Diseases associated with TPS elisa kit
Organs/Tissues associated with TPS elisa kit
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