NP_001902.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
28,837 Da
NCBI Official Full Name
cathepsin G preproprotein
NCBI Official Synonym Full Names
cathepsin G
NCBI Official Synonym Symbols
NCBI Protein Information
cathepsin G
UniProt Protein Name
Cathepsin G
UniProt Synonym Gene Names
UniProt Entry Name
CATG_HUMAN
NCBI Summary for CTSG
The protein encoded by this gene, a member of the peptidase S1 protein family, is found in azurophil granules of neutrophilic polymorphonuclear leukocytes. The encoded protease has a specificity similar to that of chymotrypsin C, and may participate in the killing and digestion of engulfed pathogens, and in connective tissue remodeling at sites of inflammation. Transcript variants utilizing alternative polyadenylation signals exist for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for CTSG
Function: Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial activity is inhibited by LPS from P.aeruginosa, Z-Gly-Leu-Phe-CH2Cl and phenylmethylsulfonyl fluoride.3 PublicationsManual assertion based on experiment in:Ref.6
Catalytic activity: Specificity similar to chymotrypsin C.
Enzyme regulation: Inhibited by soybean trypsin inhibitor, benzamidine, the synthetic peptide R13K, Z-Gly-Leu-Phe-CH2Cl, phenylmethylsulfonyl fluoride, 3,4-dichloroisocoumarin, DFP, SBTI and alpha-1-antitrypsin. Inhibited by LPS from P.aeruginosa but not by LPS from S.minnesota. Not inhibited by elastinal, CMK, TLCK and ETDA.3 PublicationsManual assertion based on experiment in:Ref.6
Research Articles on CTSG
Precautions
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Disclaimer
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Products associated with CTSG elisa kit
Pathways associated with CTSG elisa kit
Diseases associated with CTSG elisa kit
Organs/Tissues associated with CTSG elisa kit
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