NP_001129669.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
55,179 Da
NCBI Official Full Name
fizzy-related protein homolog isoform 3
NCBI Official Synonym Full Names
fizzy/cell division cycle 20 related 1 (Drosophila)
NCBI Official Synonym Symbols
FZR; CDH1; FZR2; HCDH; HCDH1; CDC20C [Similar Products]
NCBI Protein Information
fizzy-related protein homolog; CDC20-like 1b; cdh1/Hct1 homolog; CDC20-like protein 1
UniProt Protein Name
Fizzy-related protein homolog
UniProt Synonym Protein Names
CDC20-like protein 1; Cdh1/Hct1 homolog; hCDH1
UniProt Synonym Gene Names
UniProt Entry Name
FZR_HUMAN
UniProt Comments for FZR1
FZR1: Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis. The unphosphorylated form interacts with APC/C during mitosis. Interacts with NINL. Interacts (in complex with the anaphase promoting complex APC) with MAD2L2; inhibits FZR1- mediated APC/C activation. Interacts with USP37. Interacts (via WD repeats) with MAK. Isoform 2 is expressed at high levels in heart, liver, spleen and some cancer cell lines whereas isoform 3 is expressed only at low levels in these tissues. Belongs to the WD repeat CDC20/Fizzy family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component: nucleoplasm; nuclear membrane; anaphase-promoting complex; cytosol
Molecular Function: protein binding
Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; mitosis; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; anaphase-promoting complex activation; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cell division; positive regulation of cell proliferation; positive regulation of protein catabolic process; regulation of meiosis; mitotic cell cycle; G2/M transition DNA damage checkpoint; DNA repair
Research Articles on FZR1
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Products associated with FZR1 elisa kit
Pathways associated with FZR1 elisa kit
Diseases associated with FZR1 elisa kit
Organs/Tissues associated with FZR1 elisa kit
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