NP_056340.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
150,528 Da
NCBI Official Full Name
inhibitor of Bruton tyrosine kinase isoform 1
NCBI Official Synonym Full Names
inhibitor of Bruton agammaglobulinemia tyrosine kinase
NCBI Official Synonym Symbols
NCBI Protein Information
inhibitor of Bruton tyrosine kinase; BTK-binding protein; inhibitor of Bruton's tyrosine kinase; inhibitor of Bruton's tyrosine kinase-beta; inhibitor of Bruton's tyrosine kinase-alpha; inhibitor of Bruton's tyrosine kinase-gamma; Bruton agammaglobulinemia tyrosine kinase inhibitor
UniProt Protein Name
Inhibitor of Bruton tyrosine kinase
UniProt Synonym Gene Names
UniProt Entry Name
IBTK_HUMAN
NCBI Summary for IBTK
Bruton tyrosine kinase (BTK) is a protein tyrosine kinase that is expressed in B cells, macrophages, and neutrophils. The protein encoded by this gene binds to BTK and downregulates BTK's kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription. This gene has a pseudogene on chromosome 18. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]
UniProt Comments for IBTK
IBTK: Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Protein kinase, regulatory subunit
Chromosomal Location of Human Ortholog: 6q14.1
Cellular Component: nucleoplasm; membrane; cytoplasm
Molecular Function: protein tyrosine kinase inhibitor activity; protein kinase binding
Biological Process: negative regulation of protein amino acid phosphorylation; release of sequestered calcium ion into cytosol
Research Articles on IBTK
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Products associated with IBTK elisa kit
Pathways associated with IBTK elisa kit
Organs/Tissues associated with IBTK elisa kit
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