NP_004786.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
116,181 Da
NCBI Official Full Name
klotho
NCBI Official Synonym Full Names
klotho
NCBI Protein Information
klotho
UniProt Protein Name
Klotho
UniProt Entry Name
KLOT_HUMAN
NCBI Summary for KL
This gene encodes a type-I membrane protein that is related to beta-glucosidases. Reduced production of this protein has been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes (e.g., arteriosclerosis, osteoporosis, and skin atrophy) seen in CRF. Also, mutations within this protein have been associated with ageing and bone loss. [provided by RefSeq, Jul 2008]
UniProt Comments for KL
Function: May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D Essential factor for the specific interaction between FGF23 and FGFR1
Catalytic activity: A beta-D-glucuronoside + H2O = D-glucuronate + an alcohol.
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Products associated with KL elisa kit
Pathways associated with KL elisa kit
Diseases associated with KL elisa kit
Organs/Tissues associated with KL elisa kit
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