NP_001007268.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
168,600 Da
NCBI Official Full Name
secretory phospholipase A2 receptor isoform 2
NCBI Official Synonym Full Names
phospholipase A2 receptor 1, 180kDa
NCBI Official Synonym Symbols
PLA2R; PLA2-R; PLA2IR; CLEC13C; PLA2G1R [Similar Products]
NCBI Protein Information
secretory phospholipase A2 receptor; M-type receptor; phospholipase A2 receptor 1, 180kD; C-type lectin domain family 13 member C; 180 kDa secretory phospholipase A2 receptor
UniProt Protein Name
Secretory phospholipase A2 receptor
UniProt Synonym Protein Names
180 kDa secretory phospholipase A2 receptor; C-type lectin domain family 13 member C; M-type receptorCleaved into the following chain:Soluble secretory phospholipase A2 receptor; Soluble PLA2-R; Soluble PLA2R
UniProt Synonym Gene Names
UniProt Entry Name
PLA2R_HUMAN
NCBI Summary for PLA2R1
This gene represents a phospholipase A2 receptor. The encoded protein likely exists as both a transmembrane form and a soluble form. The transmembrane receptor may play a role in clearance of phospholipase A2, thereby inhibiting its action. Polymorphisms at this locus have been associated with susceptibility to idiopathic membranous nephropathy. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Sep 2010]
UniProt Comments for PLA2R1
Function: Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phosholipase sPLA2-IB/PLA2G1B but not sPLA2-IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow-derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion. May be involved in responses in proinflammatory cytokine productions during endotoxic shock. Also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPLA2s to protect their potent enzymatic activities. The soluble secretory phospholipase A2 receptor form is circulating and acts as a negative regulator of sPLA2 functions by blocking the biological functions of sPLA2-IB/PLA2G1B.2 PublicationsManual assertion based on experiment in:Ref.1
Research Articles on PLA2R1
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Products associated with PLA2R1 elisa kit
Pathways associated with PLA2R1 elisa kit
Diseases associated with PLA2R1 elisa kit
Organs/Tissues associated with PLA2R1 elisa kit
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