NP_003093.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
25,851 Da
NCBI Official Full Name
extracellular superoxide dismutase
NCBI Official Synonym Full Names
superoxide dismutase 3, extracellular
NCBI Official Synonym Symbols
NCBI Protein Information
extracellular superoxide dismutase [Cu-Zn]; extracellular superoxide dismutase [Cu-Zn]
UniProt Protein Name
Extracellular superoxide dismutase [Cu-Zn]
UniProt Synonym Gene Names
UniProt Entry Name
SODE_HUMAN
NCBI Summary for SOD3
This gene encodes a member of the superoxide dismutase (SOD) protein family. SODs are antioxidant enzymes that catalyze the dismutation of two superoxide radicals into hydrogen peroxide and oxygen. The product of this gene is thought to protect the brain, lungs, and other tissues from oxidative stress. The protein is secreted into the extracellular space and forms a glycosylated homotetramer that is anchored to the extracellular matrix (ECM) and cell surfaces through an interaction with heparan sulfate proteoglycan and collagen. A fraction of the protein is cleaved near the C-terminus before secretion to generate circulating tetramers that do not interact with the ECM. [provided by RefSeq, Jul 2008]
UniProt Comments for SOD3
SOD3: Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen. Belongs to the Cu-Zn superoxide dismutase family.
Protein type: Oxidoreductase; Secreted; Secreted, signal peptide; EC 1.15.1.1
Chromosomal Location of Human Ortholog: 4p15.2
Cellular Component: extracellular matrix; extracellular space; Golgi lumen; cytoplasm; extracellular region; trans-Golgi network; nucleus
Molecular Function: heparin binding; protein binding; copper ion binding; zinc ion binding; superoxide dismutase activity
Biological Process: response to reactive oxygen species; removal of superoxide radicals; response to copper ion; response to hypoxia
Research Articles on SOD3
Precautions
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Products associated with SOD3 elisa kit
Pathways associated with SOD3 elisa kit
Diseases associated with SOD3 elisa kit
Organs/Tissues associated with SOD3 elisa kit
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