NP_068813.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
94,770 Da
NCBI Official Full Name
suppressor of tumorigenicity 14 protein
NCBI Official Synonym Full Names
suppression of tumorigenicity 14 (colon carcinoma)
NCBI Official Synonym Symbols
HAI; MTSP1; SNC19; ARCI11; MT-SP1; PRSS14; TADG15; TMPRSS14 [Similar Products]
NCBI Protein Information
suppressor of tumorigenicity 14 protein; prostamin; serine protease 14; serine protease TADG-15; membrane-type serine protease 1; tumor associated differentially expressed gene 15 protein; tumor-associated differentially-expressed gene 15 protein; suppression of tumorigenicity 14 (colon carcinoma, matriptase, epithin)
UniProt Protein Name
Suppressor of tumorigenicity 14 protein
UniProt Synonym Protein Names
Matriptase; Membrane-type serine protease 1; MT-SP1; Prostamin; Serine protease 14; Serine protease TADG-15; Tumor-associated differentially-expressed gene 15 protein
UniProt Synonym Gene Names
UniProt Entry Name
ST14_HUMAN
NCBI Summary for ST14
The protein encoded by this gene is an epithelial-derived, integral membrane serine protease. This protease forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine 1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scattering factor, and urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other proteases and latent growth factors. The expression of this protease has been associated with breast, colon, prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis. [provided by RefSeq, Jul 2008]
UniProt Comments for ST14
ST14: Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site. Defects in ST14 are a cause of ichthyosis autosomal recessive with hypotrichosis (ARIH). ARIH is a skin disorder characterized by congenital ichthyosis associated with the presence of less than the normal amount of hair. Belongs to the peptidase S1 family.
Protein type: Protease; Membrane protein, integral; EC 3.4.21.109
Chromosomal Location of Human Ortholog: 11q24-q25
Cellular Component: extrinsic to plasma membrane; extracellular space; basolateral plasma membrane; integral to plasma membrane; plasma membrane
Molecular Function: serine-type peptidase activity; serine-type endopeptidase activity
Biological Process: keratinocyte differentiation; proteolysis
Disease: Ichthyosis, Congenital, Autosomal Recessive 11
Research Articles on ST14
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Products associated with ST14 elisa kit
Diseases associated with ST14 elisa kit
Organs/Tissues associated with ST14 elisa kit
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