NP_886552.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
50,128 Da
NCBI Official Full Name
CCA tRNA nucleotidyltransferase 1, mitochondrial
NCBI Official Synonym Full Names
tRNA nucleotidyl transferase, CCA-adding, 1
NCBI Protein Information
CCA tRNA nucleotidyltransferase 1, mitochondrial; mt CCA-adding enzyme; mt tRNA CCA-diphosphorylase; mt tRNA adenylyltransferase; mt tRNA CCA-pyrophosphorylase; tRNA-nucleotidyltransferase 1, mitochondrial; mitochondrial CCA-adding tRNA-nucleotidyltransferase; mitochondrial tRNA nucleotidyl transferase, CCA-adding
UniProt Protein Name
CCA tRNA nucleotidyltransferase 1, mitochondrial
UniProt Synonym Protein Names
Mitochondrial tRNA nucleotidyl transferase, CCA-adding; mt CCA-adding enzyme; mt tRNA CCA-diphosphorylase; mt tRNA CCA-pyrophosphorylase; mt tRNA adenylyltransferase
UniProt Synonym Gene Names
UniProt Entry Name
TRNT1_HUMAN
NCBI Summary for TRNT1
The CCA-adding enzyme TRNT1 (EC 2.7.7.25) is an essential enzyme that catalyzes the addition of the CCA terminus to the 3-prime end of tRNA precursors. This reaction is a fundamental prerequisite for mature tRNAs to become aminoacylated and to participate in protein biosynthesis (Lizano et al., 2007 [PubMed 17204286]).[supplied by OMIM, Aug 2009]
UniProt Comments for TRNT1
TRNT1: Isoform 1: Adds and repairs the conserved 3'-CCA sequence necessary for the attachment of amino acids to the 3' terminus of tRNA molecules, using CTP and ATP as substrates. Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Transferase; RNA processing; EC 2.7.7.72; Mitochondrial
Chromosomal Location of Human Ortholog: 3p25.1
Cellular Component: mitochondrion; intracellular
Molecular Function: tRNA adenylyltransferase activity; ATP binding; tRNA binding
Biological Process: tRNA 3'-terminal CCA addition; tRNA 3'-end processing; protein targeting to mitochondrion
Disease: Sideroblastic Anemia With B-cell Immunodeficiency, Periodic Fevers, And Developmental Delay
Research Articles on TRNT1
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Products associated with TRNT1 elisa kit
Pathways associated with TRNT1 elisa kit
Diseases associated with TRNT1 elisa kit
Organs/Tissues associated with TRNT1 elisa kit
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