NP_660357.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
16,563 Da
NCBI Official Full Name
unique cartilage matrix-associated protein
NCBI Official Synonym Full Names
upper zone of growth plate and cartilage matrix associated
NCBI Protein Information
unique cartilage matrix-associated protein; Gla-rich protein
UniProt Protein Name
Unique cartilage matrix-associated protein
UniProt Synonym Protein Names
Gla-rich protein; GRP
UniProt Synonym Gene Names
UniProt Entry Name
UCMA_HUMAN
NCBI Summary for UCMA
This gene encodes a chondrocyte-specific, highly charged protein that is abundantly expressed in the upper immature zone of fetal and juvenile epiphyseal cartilage. The encoded protein undergoes proteolytic processing to generate a mature protein that is secreted into the extracellular matrix. The glutamic acid residues in the encoded protein undergo gamma carboxylation in a vitamin K-dependent manner. Undercarboxylation of the encoded protein is associated with osteoarthritis in humans. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2015]
UniProt Comments for UCMA
UCMA: May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface. Belongs to the UCMA family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 10p13
Cellular Component: extracellular space; proteinaceous extracellular matrix; perinuclear region of cytoplasm
Biological Process: negative regulation of osteoblast differentiation
Research Articles on UCMA
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Organs/Tissues associated with UCMA elisa kit
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