AAL31359.1
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
ribonucleoprotein
NCBI Official Synonym Full Names
heterogeneous nuclear ribonucleoprotein M
NCBI Official Synonym Symbols
CEAR; HNRPM; HTGR1; NAGR1; HNRPM4; HNRNPM4; hnRNP M [Similar Products]
NCBI Protein Information
heterogeneous nuclear ribonucleoprotein M; CEA receptor; hnRNA-binding protein M4; N-acetylglucosamine receptor 1; heterogenous nuclear ribonucleoprotein M4
UniProt Protein Name
Heterogeneous nuclear ribonucleoprotein M
UniProt Synonym Gene Names
UniProt Entry Name
HNRPM_HUMAN
NCBI Summary for RNP
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs. This protein also constitutes a monomer of the N-acetylglucosamine-specific receptor which is postulated to trigger selective recycling of immature GlcNAc-bearing thyroglobulin molecules. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
UniProt Comments for RNP
hnRNP M: Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: RNA splicing; Nucleolus; RNA-binding; Receptor, misc.; Spliceosome
Chromosomal Location of Human Ortholog: 19p13.2
Cellular Component: nucleoplasm; spliceosome; extracellular matrix; nuclear matrix; membrane; integral to plasma membrane; nucleolus; paraspeckles
Molecular Function: protein domain specific binding; protein binding; RNA binding; nucleotide binding
Biological Process: nuclear mRNA splicing, via spliceosome; alternative nuclear mRNA splicing, via spliceosome; RNA splicing; gene expression
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Pathways associated with RNP elisa kit
Diseases associated with RNP elisa kit
Organs/Tissues associated with RNP elisa kit
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