AAD13110.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
23,616 Da
NCBI Official Full Name
Artemin
NCBI Official Synonym Full Names
artemin
NCBI Protein Information
artemin; neublastin; neurotrophic factor
UniProt Protein Name
Artemin
UniProt Synonym Protein Names
Enovin; Neublastin
UniProt Synonym Gene Names
UniProt Entry Name
ARTN_HUMAN
NCBI Summary for ART
The protein encoded by this gene is a member of the glial cell line-derived neurotophic factor (GDNF) family of ligands which are a group of ligands within the TGF-beta superfamily of signaling molecules. GDNFs are unique in having neurotrophic properties and have potential use for gene therapy in neurodegenerative disease. Artemin has been shown in culture to support the survival of a number of peripheral neuron populations and at least one population of dopaminergic CNS neurons. Its role in the PNS and CNS is further substantiated by its expression pattern in the proximity of these neurons. This protein is a ligand for the RET receptor and uses GFR-alpha 3 as a coreceptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
UniProt Comments for ART
artemin: Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain. Strong attractant of gut hematopoietic cells thus promoting the formation Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue. Belongs to the TGF-beta family. GDNF subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 1p34.1
Cellular Component: extracellular space
Molecular Function: growth factor activity; receptor binding
Biological Process: axon guidance; neuroblast proliferation; signal transduction; peripheral nervous system development; induction of positive chemotaxis
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Products associated with ART elisa kit
Pathways associated with ART elisa kit
Diseases associated with ART elisa kit
Organs/Tissues associated with ART elisa kit
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