NP_001195.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
59,963 Da
NCBI Official Full Name
bone morphogenetic protein receptor type-2
NCBI Official Synonym Full Names
bone morphogenetic protein receptor, type II (serine/threonine kinase)
NCBI Official Synonym Symbols
BMR2; PPH1; BMPR3; BRK-3; POVD1; T-ALK; BMPR-II [Similar Products]
NCBI Protein Information
bone morphogenetic protein receptor type-2; BMPR-2; BMP type-2 receptor; BMP type II receptor; type II activin receptor-like kinase; bone morphogenetic protein receptor type II; type II receptor for bone morphogenetic protein-4
UniProt Protein Name
Bone morphogenetic protein receptor type-2
UniProt Synonym Protein Names
Bone morphogenetic protein receptor type II; BMP type II receptor; BMPR-II
UniProt Synonym Gene Names
PPH1; BMP type-2 receptor; BMPR-2; BMP type II receptor; BMPR-II [Similar Products]
UniProt Entry Name
BMPR2_HUMAN
NCBI Summary for BMPRII
This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease. [provided by RefSeq, Jul 2008]
UniProt Comments for BMPRII
BMPR2: a serine/threonine-protein kinase receptor for bone morphogenetic protein (BMP). Binds to BMP-7, BMP-2 and, less efficiently, BMP-4. Binding is weak but enhanced by the presence of type I receptors for BMPs. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Defects in BMPR2 are the cause of primary pulmonary hypertension (PPH1), a weakly penetrant dominant disorder, associated with lesions in pulmonary arterioles, elevated pulmonary arterial pressure, and right ventricular failure.
Protein type: EC 2.7.11.30; Protein kinase, Ser/Thr (receptor); Membrane protein, integral; Protein kinase, TKL; Cell cycle regulation; Kinase, protein; TKL group; STKR family; Type2 subfamily
Chromosomal Location of Human Ortholog: 2q33-q34
Cellular Component: extracellular space; cell surface; cell soma; integral to plasma membrane; cytoplasm; apical plasma membrane; dendrite; basal plasma membrane; plasma membrane; caveola
Molecular Function: transforming growth factor beta receptor activity; protein binding; metal ion binding; growth factor binding; activin receptor activity, type II; ATP binding; receptor signaling protein serine/threonine kinase activity
Biological Process: limb development; transcription from RNA polymerase II promoter; regulation of lung blood pressure; negative regulation of systemic arterial blood pressure; activin receptor signaling pathway; chondrocyte development; cellular response to starvation; positive regulation of bone mineralization; protein amino acid phosphorylation; negative regulation of vasoconstriction; regulation of cell proliferation; BMP signaling pathway; anterior/posterior pattern formation; positive regulation of osteoblast differentiation; mesoderm formation; proteoglycan biosynthetic process; lymphangiogenesis; transmembrane receptor protein serine/threonine kinase signaling pathway; positive regulation of axon extension involved in axon guidance; blood vessel remodeling; positive regulation of endothelial cell proliferation; brain development; negative regulation of cell growth; vascular endothelial growth factor receptor signaling pathway; alveolus development; positive regulation of BMP signaling pathway
Disease: Pulmonary Venoocclusive Disease 1, Autosomal Dominant; Pulmonary Hypertension, Primary, 1
Research Articles on BMPRII
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Products associated with BMPRII elisa kit
Pathways associated with BMPRII elisa kit
Diseases associated with BMPRII elisa kit
Organs/Tissues associated with BMPRII elisa kit
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